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sparsentan will lower the extent or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lowers efficacy relevant to these substrates.The novel wake-endorsing agent modafinil has been in use for that treatment method of several sleep Diseas